INT333763

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il27, Il10) extracellular region (Il27, Il10) intracellular (Il10)
Il27 (Mus musculus)
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 15 92.32 High High
Arthritis 1 85.84 High High
cytokine 42 68.40 Quite High
rheumatoid arthritis 1 61.12 Quite High
Central nervous system 22 27.04 Quite Low
dexamethasone 1 7.20 Low Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 50 98.84 Very High Very High Very High
INFLAMMATION 15 92.32 High High
Disease 10 89.52 High High
Experimental Arthritis 1 87.20 High High
Epstein-barr Virus 1 79.72 Quite High
Infection 38 78.60 Quite High
Rheumatoid Arthritis 1 61.12 Quite High
Arthritis 1 57.12 Quite High
Autoimmune Disease 6 40.44 Quite Low
Central Nervous System Disease 21 27.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of vitamin D3 seems to be similar to that of IL-27, which inhibits the lineage commitment of TH17 cells [33, 41–43 51] and induces IL-10 production, which, in turn, suppresses EAE initiation [34].
IL-27 Positive_regulation (induces) of Gene_expression (production) of IL-10 associated with multiple sclerosis
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.10 Pain Relevance 0
Further study has however shown that IL-27 is also able to induce IL-10 production from Treg cells which can inhibit Th17 responses [45, 46].
IL-27 Positive_regulation (induce) of Gene_expression (production) of IL-10
2) Confidence 0.01 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.70 Pain Relevance 0.26

General Comments

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