INT333774

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1) endoplasmic reticulum (Bace1) enzyme binding (Bace1)

Anatomy Link Frequency brains 1 sal (Mus musculus) Bace1 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 6 5.00 anesthesia 3 5.00 isoflurane 3 5.00 long-term potentiation 1 5.00 sodium channel 1 5.00 imagery 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Disease Progression 3 69.12 Disease 35 47.32 Targeted Disruption 21 25.76 Alzheimer's Dementia 8 5.00 Cognitive Disorder 5 5.00 Immunization 2 5.00 Death 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Decapitation 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

with the specific phosphatase inhibitor Sal 003 elevated BACE1 levels in 6-month-old 5XFAD mouse brains.

Sal Positive_regulation (elevated) of BACE1 in brains

1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.07 Pain Relevance 0

General Comments

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