INT333877

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.03
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (LIG4) intracellular (LIG4) DNA binding (LIG4)
ligase activity (LIG4) cytoplasm (LIG4) cell proliferation (LIG4)
Anatomy Link Frequency
cleavage 2
LIG4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 98.28 Very High Very High Very High
Inflammation 32 97.88 Very High Very High Very High
Pain 2 91.84 High High
metalloproteinase 4 85.48 High High
Osteoarthritis 20 68.28 Quite High
palliative 1 53.84 Quite High
rheumatoid arthritis 16 51.52 Quite High
Arthritis 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 106 99.56 Very High Very High Very High
INFLAMMATION 31 97.88 Very High Very High Very High
Pain 2 91.84 High High
Arthritis 4 76.08 Quite High
Osteoarthritis 20 68.28 Quite High
Hepatocellular Cancer 5 67.28 Quite High
Parkinson's Disease 1 65.80 Quite High
Necrosis 3 65.72 Quite High
Cancer 20 65.36 Quite High
Death 5 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B stimulates the production of pro-inflammatory catabolic cytokines, which induce apoptosis through activation of the pro-apoptotic enzyme caspase-3 and cleavage of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP) [9].
Protein_catabolism (cleavage) of DNA repair enzyme in cleavage associated with inflammation, apoptosis and cytokine
1) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 1.10 Pain Relevance 0.52
Subsequently, the presence of activated caspase-3 is further confirmed by detecting the degradation of PARP, a DNA repair enzyme, which undergoes cleavage by caspase-3 during apoptosis.
Protein_catabolism (degradation) of repair enzyme in cleavage associated with apoptosis
2) Confidence 0.01 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.93 Pain Relevance 0.05

General Comments

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