INT333879

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

nucleus (Shc1, SOX9) mitochondrion (Shc1) aging (Shc1) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)

Shc1 (Mus musculus) SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 32 5.00 Osteoarthritis 20 5.00 rheumatoid arthritis 16 5.00 cytokine 10 5.00 metalloproteinase 4 5.00 Pain 2 5.00 Arthritis 2 5.00 dexamethasone 1 5.00 Inflammatory response 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Necrosis 3 45.08 Apoptosis 34 44.60 INFLAMMATION 31 5.00 Osteoarthritis 20 5.00 Rheumatoid Arthritis 16 5.00 Obesity 6 5.00 Cancer 5 5.00 Arthritis 4 5.00 Pain 2 5.00 Uveitis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

1-integrins, Shc, activated extracellular regulated kinases 1 and 2 (ERK 1/2) and Sox-9.

Shc Positive_regulation (activated) of Sox-9

1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.