INT333881

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
extracellular matrix 1
GAG (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 93.96 High High
Osteoarthritis 108 87.20 High High
Pain 25 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
Neurobehavioral 7 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
Bile 7 5.00 Very Low Very Low Very Low
tail-flick 6 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 93.96 High High
Osteoarthritis 86 87.20 High High
Knee Osteoarthritis 34 70.88 Quite High
Obesity 76 50.00 Quite Low
Hyperlipidemia 20 50.00 Quite Low
Targeted Disruption 15 47.88 Quite Low
Hypertrophy 1 35.20 Quite Low
Leukemia 2 19.88 Low Low
Hyperlipoproteinemia Type Ii 66 5.00 Very Low Very Low Very Low
Pain 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overlap exists principally because extensive sequences of the gag gene are retained in the vector construct to enhance the efficiency of packaging, although Gag protein production is prevented by mutation.
Gene_expression (production) of Gag protein
1) Confidence 0.75 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0 Pain Relevance 0
Leptin did not significantly affect the incorporation of [3H]proline or [35S]sulfate (Figure 6a), indicating that leptin did not alter collagen or S-GAG synthesis (major components of the extracellular matrix).
Gene_expression (synthesis) of GAG in extracellular matrix
2) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.40 Pain Relevance 0.20

General Comments

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