INT333883

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
cartilage 2
melanocyte 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 108 91.44 High High
agonist 4 84.24 Quite High
melanocortin 1 receptor 3 83.00 Quite High
adenocard 1 78.36 Quite High
Inflammation 55 71.88 Quite High
Inflammatory stimuli 4 66.12 Quite High
cytokine 26 62.48 Quite High
Inflammatory marker 4 56.60 Quite High
Inflammatory mediators 2 50.72 Quite High
Inflammatory response 2 46.92 Quite Low
Disease Link Frequency Relevance Heat
Obesity 87 92.24 High High
Osteoarthritis 86 91.44 High High
Weight Gain 3 89.80 High High
INFLAMMATION 66 71.88 Quite High
Knee Osteoarthritis 34 70.12 Quite High
Stress 5 48.48 Quite Low
Necrosis 3 31.56 Quite Low
Cancer 3 31.20 Quite Low
Hyperalgesia 7 31.16 Quite Low
Anxiety Disorder 15 30.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To directly examine whether increased levels of leptin can induce degenerative or proinflammatory changes in healthy cartilage, we treated cartilage explants with a range of physiologic doses of leptin, in the presence or absence of IL-1?
Positive_regulation (induce) of Positive_regulation (increased) of leptin in cartilage
1) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.60 Pain Relevance 0.27
POMC is upregulated in response to leptin binding and is proteolitically cleaved into several active peptides, including alpha melanocyte stimulating hormone (?
Positive_regulation (upregulated) of Positive_regulation (response) of leptin in melanocyte
2) Confidence 0.15 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.46 Pain Relevance 0.56

General Comments

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