INT333909

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 14.15
Pain Relevance 5.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
Anatomy Link Frequency
synovial cells 2
fibroblasts 2
synovium 2
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 888 99.84 Very High Very High Very High
Osteoarthritis 432 99.48 Very High Very High Very High
Inflammation 300 98.44 Very High Very High Very High
Arthritis 60 81.36 Quite High
methotrexate 48 78.88 Quite High
cINOD 48 75.76 Quite High
cytokine 60 58.88 Quite High
Inflammatory mediators 24 53.52 Quite High
corticosteroid 24 43.48 Quite Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 888 99.84 Very High Very High Very High
Frailty 456 99.48 Very High Very High Very High
INFLAMMATION 360 98.44 Very High Very High Very High
Disease 108 93.60 High High
Disease Progression 12 86.32 High High
Apoptosis 48 83.96 Quite High
Arthritis 60 81.36 Quite High
Cancer 96 75.00 Quite High
Necrosis 48 75.00 Quite High
Non-small-cell Lung Cancer 24 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
Positive_regulation (increased) of Gene_expression (expression) of HDAC1
1) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.09 Pain Relevance 0.44
The expression of HDAC1 in RASFs (n = 3) was increased after TNF?
Positive_regulation (increased) of Gene_expression (expression) of HDAC1
2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.46 Pain Relevance 0.23
Western blot analysis of class I HDACs in synovial tissues showed that the expression of HDAC1 protein was significantly increased in RA lesions, compared with OA lesions.
Positive_regulation (increased) of Gene_expression (expression) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.15 Pain Relevance 0.47
stimulation, suggesting that HDAC1 overexpression might be associated with the enhanced inflammatory reaction.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HDAC1 associated with inflammation
4) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.08 Pain Relevance 0.43
Most recently, Horiuchi et al. also showed HDAC1 is overexpressed in RASF compared to OA synovial fibroblasts [41].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HDAC1 in fibroblasts associated with osteoarthritis
5) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.24 Pain Relevance 0.36
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
Positive_regulation (after) of Gene_expression (expression) of HDAC1 mRNA
6) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.11 Pain Relevance 0.45
Second, they demonstrated lower levels of HDAC1, and HDAC2 protein in RA synovium than in OA by Western blotting of whole cell lysates, with ?
Positive_regulation (lower) of Gene_expression (levels) of HDAC1 in synovium associated with rheumatoid arthritis and osteoarthritis
7) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.58 Pain Relevance 0.72
significantly increased the nuclear HDAC activity and HDAC1 mRNA expression at 24 hours and HDAC1 protein expression at 48 hours in RASFs.


Positive_regulation (increased) of Gene_expression (expression) of HDAC1
8) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.48 Pain Relevance 0.60
Among HDACs, increased activity and expression of nuclear HDAC1 in synovial cells might play a role in RA inflammation.


Positive_regulation (increased) of Gene_expression (expression) of HDAC1 in synovial cells associated with inflammation and rheumatoid arthritis
9) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.61 Pain Relevance 0.75
significantly increased the nuclear HDAC activity and HDAC1 mRNA expression at 24 hours and HDAC1 protein expression at 48 hours in RASFs.


Positive_regulation (increased) of Gene_expression (expression) of HDAC1 mRNA
10) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.48 Pain Relevance 0.60
RA synovial tissues expressed high levels of HDAC1 compared to OA (P = 0.018), and normal controls (Figure 3a).
Positive_regulation (levels) of Gene_expression (expressed) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
11) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.48 Pain Relevance 0.74
The nuclear HDAC1 protein expression in RASFs (n = 3) was elevated compared to other class I HDACs (HDAC2, HDAC3, HDAC8) after TNF?
Positive_regulation (elevated) of Gene_expression (expression) of HDAC1
12) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.40 Pain Relevance 0.12

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