INT333914

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.04
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 148 99.84 Very High Very High Very High
Osteoarthritis 72 98.80 Very High Very High Very High
Inflammation 50 69.76 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 148 99.84 Very High Very High Very High
Frailty 76 98.80 Very High Very High Very High
Necrosis 8 78.60 Quite High
Cancer 16 78.24 Quite High
INFLAMMATION 60 69.76 Quite High
Disease 18 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Lung Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA expression of HDAC1 in RA synovial tissue was higher than in OA and normal controls, and showed positive correlation with TNF?
Transcription (expression) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.61 Pain Relevance 0.65
To investigate the expression profiles of class I and class II HDACs in RA (n = 9), OA (n = 8) and normal controls (n = 3) synovial tissues, mRNA levels of HDAC1 to 8 were evaluated by quantitative real-time PCR.
Transcription (levels) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.43 Pain Relevance 0.72

General Comments

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