INT333917

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.23
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MDM2, Trp53) enzyme binding (MDM2, Trp53) protein complex assembly (MDM2, Trp53)
protein complex (MDM2, Trp53) cytoplasm (MDM2, Trp53) cytosol (MDM2, Trp53)
MDM2 (Homo sapiens)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 99.36 Very High Very High Very High
Osteoarthritis 36 84.24 Quite High
Inflammation 25 79.72 Quite High
Arthritis 5 37.72 Quite Low
methotrexate 4 8.64 Low Low
cINOD 4 5.52 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 74 99.36 Very High Very High Very High
Apoptosis 4 92.48 High High
Frailty 38 84.24 Quite High
INFLAMMATION 30 79.72 Quite High
Cancer 8 77.08 Quite High
Disease 9 70.40 Quite High
Embryonic Lethality 1 53.56 Quite High
Necrosis 4 50.00 Quite Low
Arthritis 5 37.72 Quite Low
Disease Progression 1 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effective degradation of p53 is mediated by the ubiquitin ligase Mdm2, as well as in RA [47], and Mdm2 can promote p53 deacetylation by recruiting a complex containing HDAC1 [48].
Mdm2 Positive_regulation (mediated) of Protein_catabolism (degradation) of p53 associated with rheumatoid arthritis
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.23 Pain Relevance 0.30

General Comments

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