INT333918

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HDAC1, Trp53) enzyme binding (HDAC1, Trp53) cytoplasm (HDAC1, Trp53)
cytosol (HDAC1, Trp53) nucleolus (HDAC1, Trp53) nucleus (HDAC1, Trp53)
HDAC1 (Homo sapiens)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 90.40 High High
Inflammation 25 84.20 Quite High
Osteoarthritis 36 75.92 Quite High
Arthritis 5 42.20 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 96.96 Very High Very High Very High
Rheumatoid Arthritis 74 90.40 High High
INFLAMMATION 30 84.20 Quite High
Cancer 8 81.56 Quite High
Frailty 38 75.92 Quite High
Disease 9 74.88 Quite High
Embryonic Lethality 1 58.04 Quite High
Necrosis 4 50.00 Quite Low
Arthritis 5 42.20 Quite Low
Disease Progression 1 34.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that HDAC1 deacetylates p53 in vitro and in vivo, and down-regulates p53 transcriptional activity [45,46].
HDAC1 Regulation (regulates) of p53
1) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.24 Pain Relevance 0.30

General Comments

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