INT333924

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 1.24

cell differentiation (TDGF1) extracellular space (TDGF1) Golgi apparatus (TDGF1) plasma membrane (TDGF1) nucleus (TDGF1) embryo development (TDGF1)

Anatomy Link Frequency posterior 1 TDGF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 72 100.00 Fibrositis 77 97.76 gABA 2 93.24 Pain 48 89.12 insula 2 39.92 Lasting pain 1 21.72 imagery 57 5.00 depression 18 5.00 Hippocampus 12 5.00 Thalamus 6 5.00

Disease Link Frequency Relevance Heat Fibromyalgia 77 97.76 Pain 47 89.12 Pressure And Volume Under Development 5 81.80 Chronic Disease 1 61.56 Attention Deficit Hyperactivity Disorder 1 55.16 Depression 16 5.00 Congenital Anomalies 6 5.00 Anxiety Disorder 6 5.00 Cognitive Disorder 5 5.00 Mixed Anxiety And Depression 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One of the principal findings in our study was the increase in the combined glutamate+glutamine (Glx) levels and glutamate+glutamine/creatine ratio (Glx/Cr) in the posterior gyrus (Figure 3) in individuals with FM compared with controls.

Positive_regulation (increase) of Cr in posterior associated with glutamate and fibrositis

1) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945024 Disease Relevance 1.03 Pain Relevance 1.24

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