INT333925

Context Info Confidence 0.26 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 1.17

lyase activity (GLO1) carbohydrate metabolic process (GLO1) cytoplasm (GLO1)

Anatomy Link Frequency posterior 2 GLO1 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 72 100.00 depression 18 100.00 Pain 48 97.08 imagery 57 87.56 excitatory amino acid 2 78.20 Fibrositis 77 73.56 gABA 2 58.24 Thalamus 6 49.24 Neurotransmitter 2 42.48 Hippocampus 12 5.00

Disease Link Frequency Relevance Heat Depression 16 100.00 Pain 47 97.08 Fibromyalgia 77 73.56 Fatigue 3 62.60 Stress 1 53.92 Congenital Anomalies 6 5.00 Anxiety Disorder 6 5.00 Cognitive Disorder 5 5.00 Pressure And Volume Under Development 5 5.00 Mixed Anxiety And Depression 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In our study, a significant correlation was noted in the posterior gyrus between Glx levels and Glx/Cr ratios with depression (higher levels of glutamate correlated with higher depression scoring), pain measured with a sphygmomanometer (high levels of glutamate correlated with lower sphygmomanometer pressure, which means more proneness to experiencing pain), and global function assessed with FIQ (higher levels of glutamate levels correlated with worse global function).

Negative_regulation (depression) of Gene_expression (ratios) of Glx in posterior associated with pain, glutamate and depression

1) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945024 Disease Relevance 0.89 Pain Relevance 1.17

General Comments

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