INT333927

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA5) mitochondrion (GLUL) small molecule metabolic process (GLUL)
lyase activity (GLUL) endoplasmic reticulum (HSPA5) Golgi apparatus (GLUL)
GLUL (Homo sapiens)
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 96.08 Very High Very High Very High
Osteoarthritis 54 94.92 High High
cytokine 16 69.52 Quite High
Pain 8 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 96.08 Very High Very High Very High
Osteoarthritis 54 94.92 High High
Stress 18 91.44 High High
Rheumatoid Arthritis 2 88.00 High High
Disease 8 62.40 Quite High
Pain 8 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, GS remarkably increases another UPR-related protein, GRP78 (BiP), a fact that we confirmed both at transcript and protein levels.
GS Positive_regulation (increases) of GRP78
1) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.43 Pain Relevance 0.15
The chaperone GRP78 was found to be remarkably increased by GS alone and in combination with CS, a fact that unveils a putative mechanism for the reported anti-inflammatory effect of GS in OA.
GS Positive_regulation (increased) of GRP78 associated with inflammation and osteoarthritis
2) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945029 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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