INT33393

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.35
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 16
smooth muscle 2
endothelial cells 2
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 99.98 Very High Very High Very High
Serotonin 1 99.90 Very High Very High Very High
aspirin 73 98.86 Very High Very High Very High
corticosteroid 5 96.94 Very High Very High Very High
Inflammation 97 94.78 High High
Bioavailability 4 94.08 High High
Migraine 1 91.80 High High
Angina 18 91.28 High High
antagonist 19 89.76 High High
TRP channel 1 84.64 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 152 99.66 Very High Very High Very High
Thrombosis 54 99.28 Very High Very High Very High
Thrombocytopenia 49 98.16 Very High Very High Very High
Hyperplasia 2 97.68 Very High Very High Very High
Atherosclerosis 19 97.48 Very High Very High Very High
Adhesions 35 97.12 Very High Very High Very High
Coagulation Disorder 3 96.96 Very High Very High Very High
Increased Venous Pressure Under Development 43 95.60 Very High Very High Very High
INFLAMMATION 135 94.78 High High
Diabetes Mellitus 52 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the relatively weak antiplatelet effects of aspirin, agonists such as thrombin, collagen, and serotonin can induce the functional expression of the platelet GP IIb/IIIa receptor.
Positive_regulation (induce) of Gene_expression (expression) of platelet in platelet associated with aspirin, agonist and serotonin
1) Confidence 0.67 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.50 Pain Relevance 0.29
HDL inhibit agonist-induced production of platelet-activating factor (PAF), a bioactive phospholipid that stimulates cell adhesion, platelet aggregation, and vascular permeability in endothelial cells (Sugatani et al 1996).
Positive_regulation (induced) of Gene_expression (production) of platelet in endothelial cells associated with agonist, adhesions and disorder of lipid metabolism
2) Confidence 0.67 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.28 Pain Relevance 0.05
The aim of this study was to examine whether beta-blocking drugs interfere with platelet beta- adrenoceptors and whether this dependency is related to their selectivity for beta-adrenoceptor subtypes.
Spec (whether) Positive_regulation (interfere) of Gene_expression (interfere) of platelet in platelet
3) Confidence 0.49 Published 1985 Journal Thromb. Res. Section Abstract Doc Link 3003961 Disease Relevance 0.37 Pain Relevance 0.35
Corticosteroids inhibit rostaglandins and inflammatory adhesion molecules, thus contribute to the stabilization of the blood-retinal barrier.13-15 Corticosteroids also inhibit expression of the vascular endothelial growth factor (VEGF), as well as the induction of VEGF by platelet-derived growth factor (PEGF) and platelet activating factor (PAF).16
Positive_regulation (activating) of Gene_expression (factor) of platelet in platelet associated with corticosteroid, inflammation and adhesions
4) Confidence 0.49 Published 2007 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629885 Disease Relevance 1.14 Pain Relevance 0.35
Diabetes was associated with an increase in plaque area and complexity in the aorta, in association with a significant increase in aortic AT-1 receptor expression, cellular proliferation, collagen content, and macrophage-positive and alpha-smooth muscle actin-positive cell infiltration, as well as an increased expression of platelet-derived growth factor-B (PDGF-B), monocyte chemoattractant protein-1 (MCP-1), and vascular cell adhesion molecule-1 (VCAM-1).
Positive_regulation (increased) of Gene_expression (expression) of platelet in smooth muscle associated with diabetes mellitus, adhesions and hyperplasia
5) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.83 Pain Relevance 0.06
The importance of SOCE for platelet activation, hemostasis, and thrombosis, however, remains unknown, and the mechanisms underlying the process are not defined.
Positive_regulation (importance) of Gene_expression (activation) of platelet in platelet associated with thrombosis
6) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.32 Pain Relevance 0.04
For the first time we find that increased platelet P2Y12 receptor protein expression is a component of clopidogrel resistance.
Positive_regulation (increased) of Gene_expression (expression) of platelet in platelet
7) Confidence 0.49 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.15 Pain Relevance 0.20
Platelet FcR surface expression is increased in patients with an acute coronary or cerebrovascular event, non-acutely ill patients with two or more ARFs, and in patients with diabetes mellitus.
Positive_regulation (increased) of Gene_expression (expression) of Platelet in Platelet associated with diabetes mellitus
8) Confidence 0.49 Published 2002 Journal Atherosclerosis Section Abstract Doc Link 12204796 Disease Relevance 0.66 Pain Relevance 0.08
This observation indicates that oxaliplatin-induced platelet antibodies do not cross-react with other chemotherapeutic agents.
Positive_regulation (induced) of Gene_expression (antibodies) of platelet in platelet
9) Confidence 0.49 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2859393 Disease Relevance 0.99 Pain Relevance 0
Oral bacteria including Streptococcus sanguis and P. gingivalis have been shown to result in the expression of platelet aggregation proteins that may play a role in the formation of atheromas and thrombi possibly contributing to vascular disease (Herzberg and Meyer 1996, 1998; Sharma et al 2000; Pham et al 2002).
Positive_regulation (result) of Gene_expression (expression) of platelet in platelet associated with atherosclerosis and increased venous pressure under development
10) Confidence 0.45 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.12 Pain Relevance 0.22

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