INT333957

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA5) endoplasmic reticulum (HSPA5) ATPase activity (HSPA5)
nucleus (HSPA5) protein binding, bridging (HSPA5)
Anatomy Link Frequency
reticulum 1
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 90.16 High High
cytokine 16 45.28 Quite Low
dopamine receptor 1 40.20 Quite Low
Inflammation 16 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 55 90.16 High High
Stress 18 65.20 Quite High
Disease 8 45.96 Quite Low
Knee Osteoarthritis 2 23.68 Low Low
Adhesions 2 9.72 Low Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Verification of the modulation of GRP78 and SOD2
Regulation (modulation) of GRP78
1) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.14 Pain Relevance 0.07
2-DE: two-dimensional electrophoresis; cDNA: complementary DNA; CS: chondroitin sulfate; Ct: threshold cycle; DMEM, Dulbecco's modified Eagle's medium; ECM: extracellular matrix; ER: endoplasmic reticulum; FCS: fetal calf serum; GRP78: glucose regulated protein 78; GS: Glucosamine sulfate; IEF: isoelectric focusing; IL-1?
Regulation (regulated) of GRP78 in reticulum
2) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.47 Pain Relevance 0.20
Then, we tested the effect of lowering the levels of functional chaperones expressed with inhibitory RNA (Efficiency of inhibition shown in additional file 2: Figure S2) or a mutated inactive form of Bip.
Regulation (effect) of Bip
3) Confidence 0.13 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0

General Comments

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