INT333961

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.67
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6r) extracellular region (Il6r) enzyme binding (Il6r)
Il6r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 99.74 Very High Very High Very High
agonist 5 98.58 Very High Very High Very High
Arthritis 255 95.04 Very High Very High Very High
Inflammation 150 94.08 High High
rheumatoid arthritis 5 92.76 High High
c fibre 5 85.96 High High
hyperexcitability 30 81.68 Quite High
cytokine 20 80.52 Quite High
nociceptor 10 78.80 Quite High
IPN 5 77.52 Quite High
Disease Link Frequency Relevance Heat
Arthritis 295 95.04 Very High Very High Very High
INFLAMMATION 135 94.08 High High
Rheumatoid Arthritis 5 92.76 High High
Necrosis 10 90.24 High High
Cancer 10 89.88 High High
Nociception 25 85.60 High High
Inflammatory Pain 5 77.52 Quite High
Pain 110 50.00 Quite Low
Hyperalgesia 95 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensitizing effect of IL-6 was prevented by co-administration of sgp130 which binds and inactivates IL-6/IL-6R complexes [5].
IL-6R Binding (binds) of
1) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.48 Pain Relevance 0.44
Alternatively, IL-6 can bind to a soluble IL-6 receptor (sIL-6R), and the IL-6/sIL-6R complex can bind to the transmembrane signal-transducing subunit gp130 of cells which do not express the membrane-bound IL-6R, thus leading to IL-6 transsignalling [5].
sIL-6R Binding (bind) of
2) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.82 Pain Relevance 0.43
Alternatively, IL-6 can bind to a soluble IL-6 receptor (sIL-6R), and the IL-6/sIL-6R complex can bind to the transmembrane signal-transducing subunit gp130 of cells which do not express the membrane-bound IL-6R, thus leading to IL-6 transsignalling [5].
sIL-6R Binding (bind) of
3) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.78 Pain Relevance 0.41
While sIL-6R acts as an agonist, circulating soluble gp130 (sgp130) acts as an antagonist, because it binds IL-6/sIL-6R complexes and thus prevents transsignalling [4,5].
sIL-6R Binding (binds) of associated with antagonist and agonist
4) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.84 Pain Relevance 0.62
IL-6 can bind to a membrane-bound IL-6 receptor (IL-6R) which acts in cooperation with the transmembrane signal-transducing subunit soluble glycoprotein 130 (gp130) [4,5].
IL-6R Binding (bind) of
5) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.76 Pain Relevance 0.38

General Comments

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