INT333966

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.74
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6r, Il6st) signal transduction (Il6st) extracellular region (Il6r)
enzyme binding (Il6r) cellular_component (Il6st)
Il6r (Rattus norvegicus)
Il6st (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
agonist 2 99.56 Very High Very High Very High
Arthritis 102 95.04 Very High Very High Very High
rheumatoid arthritis 2 94.72 High High
Inflammation 60 86.64 High High
IPN 2 77.52 Quite High
nociceptor 4 72.56 Quite High
cytokine 8 70.84 Quite High
c fibre 2 58.00 Quite High
Pain 50 50.00 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 118 95.04 Very High Very High Very High
Rheumatoid Arthritis 2 94.72 High High
INFLAMMATION 54 86.64 High High
Necrosis 4 80.56 Quite High
Cancer 4 80.20 Quite High
Inflammatory Pain 2 77.52 Quite High
Nociception 10 58.96 Quite High
Pain 44 50.00 Quite Low
Hyperalgesia 38 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While sIL-6R acts as an agonist, circulating soluble gp130 (sgp130) acts as an antagonist, because it binds IL-6/sIL-6R complexes and thus prevents transsignalling [4,5].
sIL-6R Binding (binds) of gp130 associated with antagonist and agonist
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.91 Pain Relevance 0.66
Alternatively, IL-6 can bind to a soluble IL-6 receptor (sIL-6R), and the IL-6/sIL-6R complex can bind to the transmembrane signal-transducing subunit gp130 of cells which do not express the membrane-bound IL-6R, thus leading to IL-6 transsignalling [5].
sIL-6R Binding (bind) of gp130
2) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.83 Pain Relevance 0.44

General Comments

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