INT333969

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.28
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, Cd4) intracellular (TNF) enzyme binding (Cd4)
extracellular matrix organization (TNF) extracellular space (TNF) signal transduction (TNF)
Anatomy Link Frequency
T cells 1
TNF (Homo sapiens)
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 33 98.52 Very High Very High Very High
Infliximab 3 81.60 Quite High
Adalimumab 3 80.40 Quite High
cytokine 4 12.96 Low Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 33 98.52 Very High Very High Very High
Alagille Syndrome 32 97.66 Very High Very High Very High
Cytomegalovirus Infection 87 97.58 Very High Very High Very High
Autoimmune Disease 1 81.32 Quite High
Mycobacterial Infection 3 74.80 Quite High
Hepatitis B Virus Infection 1 62.72 Quite High
Hepatitis C Virus Infection 1 52.08 Quite High
Epstein-barr Virus 7 50.32 Quite High
Necrosis 3 50.00 Quite Low
Cancer 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significant response of CD4pos T cells from peripheral blood at day 0 of treatment and the relatively stable anti-CMV response over the course of treatment in our current study suggest (a) that anergy to anti-CMV Ags, if any, was not a prominent feature of RA patients; and (b) that anti-TNF treatments did not restore function from CD4pos T cells putatively engaged in anergy or in TNF-?
TNF Binding (engaged) of CD4pos in T cells associated with alagille syndrome, rheumatoid arthritis and cytomegalovirus infection
1) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945035 Disease Relevance 1.28 Pain Relevance 0.39

General Comments

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