INT333986

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 3
leukocyte 1
TRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 50.00 Quite Low
Potency 5 40.08 Quite Low
Pain 11 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Splenomegaly 2 97.52 Very High Very High Very High
Hepatomegaly 2 95.92 Very High Very High Very High
Gauchers Disease 60 85.36 High High
Respiratory Syncytial Virus 116 84.04 Quite High
Hypertension 2 29.20 Quite Low
Hypercalcemia 14 27.84 Quite Low
Necrosis 18 20.80 Low Low
Spontaneous Fractures 13 12.16 Low Low
Compression Fractures 6 5.84 Low Low
Disease 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Negative_regulation (decreased) of Gene_expression (levels) of TRAP in platelet
1) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Negative_regulation (decreased) of in leukocyte Gene_expression (levels) of TRAP in platelet
2) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
Supplementation of the culture media with either PDM10 or PDM11 reduced the levels of TRAP activity released into the culture media (Supplementary Fig. 1) and suppressed the expression of cathepsin K in a dose-dependent fashion.
Negative_regulation (suppressed) of Gene_expression (expression) of TRAP
3) Confidence 0.07 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.21 Pain Relevance 0

General Comments

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