INT33399

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.97
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CDS1) endoplasmic reticulum (CDS1) nucleotidyltransferase activity (CDS1)
Anatomy Link Frequency
chondrocyte 1
CSF 1
brain 1
fundus 1
vas deferens 1
CDS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 20 100.00 Very High Very High Very High
dexamethasone 4 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
antagonist 3 99.84 Very High Very High Very High
depression 6 99.80 Very High Very High Very High
Enkephalin 4 99.48 Very High Very High Very High
agonist 2 99.04 Very High Very High Very High
Angina 7 98.80 Very High Very High Very High
aspirin 1 98.46 Very High Very High Very High
antidepressant 2 91.52 High High
Disease Link Frequency Relevance Heat
Depression 5 99.80 Very High Very High Very High
Cv General 3 Under Development 6 98.80 Very High Very High Very High
Metastasis 1 94.24 High High
Cancer 1 92.16 High High
Stroke 2 91.20 High High
Malignant Neoplastic Disease 1 90.80 High High
Depressive Disorder 1 90.16 High High
Meningitis 1 89.84 High High
Neurological Disease 1 84.52 Quite High
INFLAMMATION 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the CDS inhibition of the twitch response is reversed by two alpha 2-adrenergic antagonists, yohimbine and phentolamine.
Negative_regulation (inhibition) of CDS associated with antagonist
1) Confidence 0.37 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3004427 Disease Relevance 0 Pain Relevance 0.52
The effective dose of CDS as an inhibitor of the vas deferens is equivalent to its effective dose in displacing specifically bound [3H]-clonidine in rat brain membranes.
Negative_regulation (inhibitor) of CDS in vas deferens associated with clonidine
2) Confidence 0.37 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3004427 Disease Relevance 0 Pain Relevance 0.52
We conclude that CDS is present and can be measured in human CSF.
Negative_regulation (measured) of CDS in CSF
3) Confidence 0.36 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431781 Disease Relevance 0.63 Pain Relevance 0.33
The contractile effect of CDS was not blocked by antagonists selective for biologically active substances known to contract the fundus strip.
Negative_regulation (blocked) of CDS in fundus associated with antagonist
4) Confidence 0.36 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3480808 Disease Relevance 0 Pain Relevance 0.30
The decreases in CDs in patients with vasospastic angina observed after ergonovine administration were greater than those in control patients (-18 +/- 2% vs -9 +/- 2%, respectively; p < 0.05).
Negative_regulation (decreases) of CDs associated with angina
5) Confidence 0.36 Published 1994 Journal Am. J. Cardiol. Section Abstract Doc Link 7977037 Disease Relevance 0.61 Pain Relevance 0.54
Aspirin significantly stimulated chondrocyte synthetic activity in the presence and absence of CDS.
Negative_regulation (absence) of CDS in chondrocyte associated with aspirin
6) Confidence 0.36 Published 2002 Journal Vet. Ther. Section Abstract Doc Link 19750743 Disease Relevance 0.07 Pain Relevance 0.21
HP beta CD has contributed to the development and preclinical/clinical testing of a number of CDS including E2 (estradiol)-CDS, AZT (zidovudine)-CDS, DEX (dexamethasone)-CDS and a neuropeptide CDS based on an enkephalin derivative.
Negative_regulation (number) of CDS associated with neuropeptide, enkephalin and dexamethasone
7) Confidence 0.32 Published 2002 Journal Pharmazie Section Abstract Doc Link 11878196 Disease Relevance 0 Pain Relevance 0.23
HP beta CD has contributed to the development and preclinical/clinical testing of a number of CDS including E2 (estradiol)-CDS, AZT (zidovudine)-CDS, DEX (dexamethasone)-CDS and a neuropeptide CDS based on an enkephalin derivative.
Negative_regulation (number) of CDS associated with neuropeptide, enkephalin and dexamethasone
8) Confidence 0.32 Published 2002 Journal Pharmazie Section Abstract Doc Link 11878196 Disease Relevance 0 Pain Relevance 0.24
HP beta CD has contributed to the development and preclinical/clinical testing of a number of CDS including E2 (estradiol)-CDS, AZT (zidovudine)-CDS, DEX (dexamethasone)-CDS and a neuropeptide CDS based on an enkephalin derivative.
Negative_regulation (number) of CDS associated with neuropeptide, enkephalin and dexamethasone
9) Confidence 0.32 Published 2002 Journal Pharmazie Section Abstract Doc Link 11878196 Disease Relevance 0 Pain Relevance 0.24
HP beta CD has contributed to the development and preclinical/clinical testing of a number of CDS including E2 (estradiol)-CDS, AZT (zidovudine)-CDS, DEX (dexamethasone)-CDS and a neuropeptide CDS based on an enkephalin derivative.
Negative_regulation (number) of CDS associated with neuropeptide, enkephalin and dexamethasone
10) Confidence 0.32 Published 2002 Journal Pharmazie Section Abstract Doc Link 11878196 Disease Relevance 0 Pain Relevance 0.24
The results showed that a significant reduction of CDS was achieved by using VivaSens or Seal&Protect after both one week and six months.
Negative_regulation (reduction) of CDS
11) Confidence 0.31 Published 2010 Journal Swed Dent J Section Abstract Doc Link 20701216 Disease Relevance 0.26 Pain Relevance 0.21
A hypothesis for depletion of brain clonidine-displacing substance (CDS) in depression is presented.
Negative_regulation (depletion) of CDS in brain associated with depression and clonidine
12) Confidence 0.03 Published 1994 Journal Crit Rev Neurobiol Section Abstract Doc Link 8828003 Disease Relevance 0.40 Pain Relevance 0.63

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