INT334015

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.32
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
macrophages 2
blood 1
monocytes 1
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 624 99.84 Very High Very High Very High
antagonist 18 98.56 Very High Very High Very High
cytokine 30 97.40 Very High Very High Very High
chemokine 180 95.68 Very High Very High Very High
Arthritis 24 94.76 High High
Inflammation 60 89.88 High High
Crohn's disease 24 78.08 Quite High
Etanercept 6 46.08 Quite Low
methotrexate 12 45.12 Quite Low
Leflunomide 6 44.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 738 99.84 Very High Very High Very High
Disease 96 97.80 Very High Very High Very High
Arthritis 30 94.76 High High
Reprotox - General 1 6 88.36 High High
Cancer 18 86.00 High High
Leukemia 6 80.80 Quite High
Inflammatory Bowel Disease 6 75.72 Quite High
INFLAMMATION 48 73.36 Quite High
Acute Monocytic Leukemia 12 63.68 Quite High
Necrosis 12 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This implies the existence of CCR9 on activated monocytes and macrophages; however, there has been a lack of studies of CCR9 on these cells in humans and mice.
Regulation (implies) of CCR9 in macrophages
1) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.09 Pain Relevance 0.37
The mechanism behind the up-regulation of CCR9 on monocytes in the blood is unknown but may relate to elevated cytokines, such as TNF?
Regulation (regulation) of CCR9 in blood associated with cytokine
2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.48 Pain Relevance 0.34
It is unknown, as yet, whether CCR9 is modulated during monocyte differentiation and differentially expressed by polarized (M1 and M2) macrophages, together with the effect of CCL25 on markers of macrophage polarization.
Spec (whether) Regulation (modulated) of CCR9 in macrophage
3) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.44 Pain Relevance 0.27
Therefore CCR9 may be an interesting therapeutic target in RA and suggests the use of CCR9 antagonists in the disease.


Regulation (target) of CCR9 associated with antagonist, rheumatoid arthritis and disease
4) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.36 Pain Relevance 0.75
There have been no studies targeting CCR9 in these adaptive immune response models and it would be interesting to perform such a study.
Neg (no) Regulation (targeting) of CCR9
5) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.87 Pain Relevance 0.59
This implies the existence of CCR9 on activated monocytes and macrophages; however, there has been a lack of studies of CCR9 on these cells in humans and mice.
Regulation (implies) of CCR9 in monocytes
6) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.09 Pain Relevance 0.37

General Comments

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