INT334016

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.05
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
blood 1
macrophage 1
monocyte 1
T lymphocytes 1
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 520 99.60 Very High Very High Very High
chemokine 150 95.68 Very High Very High Very High
Inflammation 50 94.44 High High
cytokine 25 91.24 High High
antagonist 15 85.68 High High
Crohn's disease 20 72.36 Quite High
Arthritis 20 55.00 Quite High
methotrexate 10 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 615 99.60 Very High Very High Very High
Arthritis 25 94.44 High High
Disease 80 85.16 High High
INFLAMMATION 40 77.72 Quite High
Acute Monocytic Leukemia 10 52.24 Quite High
Cancer 15 48.88 Quite Low
Necrosis 10 48.32 Quite Low
Hypersensitivity 10 5.68 Low Low
Adhesions 15 5.00 Very Low Very Low Very Low
Synovitis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is unknown, as yet, whether CCR9 is modulated during monocyte differentiation and differentially expressed by polarized (M1 and M2) macrophages, together with the effect of CCL25 on markers of macrophage polarization.
Localization (modulated) of CCR9 in macrophage
1) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.44 Pain Relevance 0.27
CCR9 co-localised with CD14 (Figure 2a-c) and CD68 (Figure 2d-f) in RA and non-RA synovia.
Localization (localised) of CCR9 associated with rheumatoid arthritis
2) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.87 Pain Relevance 0.47
No co-localisation was observed between CCR9 and CD20 (B lymphocytes) or CD3 (T lymphocytes) respectively in either RA or non-RA synovia (data not shown).
Localization (localisation) of CCR9 in T lymphocytes associated with rheumatoid arthritis
3) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.99 Pain Relevance 0.52
This increased responsiveness may be related to the increased abundance of CCR9 found on RA blood monocytes, as shown by the MFI flow cytometry data.
Localization (abundance) of CCR9 in blood associated with rheumatoid arthritis
4) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.51 Pain Relevance 0.32
The present study shows the presence of CCR9 on monocytes/macrophges in RA where this receptor stimulates monocyte differentiation.
Localization (presence) of CCR9 in monocyte associated with rheumatoid arthritis
5) Confidence 0.68 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.23 Pain Relevance 0.75

General Comments

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