INT334019

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.00
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
macrophages 1
monocytes 1
THP-1 1
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 312 98.68 Very High Very High Very High
cytokine 15 85.52 High High
chemokine 90 79.44 Quite High
Etanercept 3 73.92 Quite High
methotrexate 6 72.96 Quite High
Leflunomide 3 71.84 Quite High
Inflammation 30 60.72 Quite High
fibrosis 3 23.44 Low Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 369 98.68 Very High Very High Very High
Disease 48 98.28 Very High Very High Very High
Reprotox - General 1 3 73.92 Quite High
Cancer 9 71.56 Quite High
Leukemia 3 66.36 Quite High
Inflammatory Bowel Disease 3 61.28 Quite High
INFLAMMATION 24 58.92 Quite High
Synovitis 6 35.68 Quite Low
Fibrosis 3 23.44 Low Low
Adhesions 9 17.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-stimulated up-regulation of CCR9 on THP-1 cells
Positive_regulation (up-regulation) of CCR9 in THP-1
1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.50 Pain Relevance 0.33
Therefore we examined the expression and function of CCR9 by monocytes and macrophages in RA.


Spec (examined) Positive_regulation (function) of CCR9 in monocytes associated with rheumatoid arthritis
2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.25 Pain Relevance 0.50
Therefore we examined the expression and function of CCR9 by monocytes and macrophages in RA.


Spec (examined) Positive_regulation (function) of CCR9 in macrophages associated with rheumatoid arthritis
3) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.25 Pain Relevance 0.50

General Comments

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