INT334019

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.00 Pain Relevance 1.33

plasma membrane (CCR9) signal transducer activity (CCR9)

Anatomy Link Frequency macrophages 1 monocytes 1 THP-1 1 CCR9 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 312 98.68 cytokine 15 85.52 chemokine 90 79.44 Etanercept 3 73.92 methotrexate 6 72.96 Leflunomide 3 71.84 Inflammation 30 60.72 fibrosis 3 23.44 Crohn's disease 12 5.00 Arthritis 12 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 369 98.68 Disease 48 98.28 Reprotox - General 1 3 73.92 Cancer 9 71.56 Leukemia 3 66.36 Inflammatory Bowel Disease 3 61.28 INFLAMMATION 24 58.92 Synovitis 6 35.68 Fibrosis 3 23.44 Adhesions 9 17.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-stimulated up-regulation of CCR9 on THP-1 cells

Positive_regulation (up-regulation) of CCR9 in THP-1

1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.50 Pain Relevance 0.33

Therefore we examined the expression and function of CCR9 by monocytes and macrophages in RA.

Spec (examined) Positive_regulation (function) of CCR9 in monocytes associated with rheumatoid arthritis

2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.25 Pain Relevance 0.50

Therefore we examined the expression and function of CCR9 by monocytes and macrophages in RA.

Spec (examined) Positive_regulation (function) of CCR9 in macrophages associated with rheumatoid arthritis

3) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.25 Pain Relevance 0.50

General Comments

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