INT334020

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.22
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
macrophages 1
monocytes 1
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 208 90.96 High High
chemokine 60 90.04 High High
Inflammation 20 71.32 Quite High
Etanercept 2 53.28 Quite High
methotrexate 4 52.32 Quite High
Leflunomide 2 51.20 Quite High
cytokine 10 22.08 Low Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 246 90.96 High High
Disease 32 84.64 Quite High
Reprotox - General 1 2 84.52 Quite High
Cancer 6 82.16 Quite High
Leukemia 2 76.96 Quite High
Inflammatory Bowel Disease 2 71.88 Quite High
INFLAMMATION 16 69.52 Quite High
Adhesions 6 28.48 Quite Low
Synovitis 4 15.04 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This implies the existence of CCR9 on activated monocytes and macrophages; however, there has been a lack of studies of CCR9 on these cells in humans and mice.
Negative_regulation (lack) of CCR9 in macrophages
1) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.11 Pain Relevance 0.43
This implies the existence of CCR9 on activated monocytes and macrophages; however, there has been a lack of studies of CCR9 on these cells in humans and mice.
Negative_regulation (lack) of CCR9 in monocytes
2) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.11 Pain Relevance 0.43

General Comments

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