INT334022

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.97
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
monocytes 4
macrophages 3
blood 2
THP-1 2
bone marrow 1
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 728 99.60 Very High Very High Very High
cytokine 35 96.88 Very High Very High Very High
chemokine 210 82.96 Quite High
Inflammation 70 45.48 Quite Low
Crohn's disease 28 5.00 Very Low Very Low Very Low
Arthritis 28 5.00 Very Low Very Low Very Low
antagonist 21 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 861 99.84 Very High Very High Very High
Acute Monocytic Leukemia 14 99.60 Very High Very High Very High
Necrosis 14 99.16 Very High Very High Very High
Cancer 21 98.80 Very High Very High Very High
Disease 112 96.12 Very High Very High Very High
INFLAMMATION 56 45.48 Quite Low
Adhesions 21 6.64 Low Low
Arthritis 35 5.00 Very Low Very Low Very Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Synovitis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
results in increased CCR9 expression.
Positive_regulation (increased) of Gene_expression (expression) of CCR9
1) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.42 Pain Relevance 0.28
Therefore the increase in the expression of CCR9 may be related to the enhanced activation state of monocytes/macrophages in the RA circulation and synovial tissue.
Positive_regulation (increase) of Gene_expression (expression) of CCR9 in macrophages associated with rheumatoid arthritis
2) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.50 Pain Relevance 0.32
The results of this study show an increased expression of CCR9 on circulating monocytes in the blood of patients with RA.
Positive_regulation (increased) of Gene_expression (expression) of CCR9 in blood associated with rheumatoid arthritis
3) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.96 Pain Relevance 0.52
increased CCR9 expression on human acute monocytic leukemia cell line THP-1 monocytic cells.
Positive_regulation (increased) of Gene_expression (expression) of CCR9 in THP-1 associated with acute monocytic leukemia
4) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945064 Disease Relevance 1.66 Pain Relevance 0.17
Alternatively the increased CCR9 expression on monocytes may be due to changes occurring in the bone marrow which are known to occur in the disease [38-40].
Positive_regulation (increased) of in monocytes Gene_expression (expression) of CCR9 in bone marrow associated with disease
5) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.45 Pain Relevance 0.33
CCR9 expression by monocytes is increased in RA.
Positive_regulation (increased) of Gene_expression (expression) of CCR9 in monocytes associated with rheumatoid arthritis
6) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945064 Disease Relevance 1.47 Pain Relevance 0.13
Therefore the increase in the expression of CCR9 may be related to the enhanced activation state of monocytes/macrophages in the RA circulation and synovial tissue.
Positive_regulation (increase) of in monocytes Gene_expression (expression) of CCR9 in macrophages associated with rheumatoid arthritis
7) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.50 Pain Relevance 0.32

General Comments

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