INT334039

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdt1) DNA binding (Cdt1)
Cdt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 10 74.24 Quite High
cINOD 10 27.72 Quite Low
COX2 6 12.40 Low Low
analgesia 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 82 98.84 Very High Very High Very High
Apoptosis 30 70.76 Quite High
Lifespan 18 60.12 Quite High
Cancer 2 48.08 Quite Low
Fracture Healing 6 19.20 Low Low
INFLAMMATION 6 16.08 Low Low
Metabolic Bone Disease 2 10.16 Low Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concomitant increased expression of COX-2 and b-ALP genes after treatment with Ris suggests a direct effect on osteogenic differentiation of mesenchymal precursors.
Positive_regulation (increased) of Gene_expression (expression) of Ris
1) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.49 Pain Relevance 0.03
Furthermore, increased COX-2 gene expression observed with Ris was maintained even in the presence of GC, suggesting that Ris counteracts negative effects of GC on osteoblastic lineage.


Positive_regulation (increased) of Gene_expression (expression) of Ris associated with osteoporosis
2) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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