INT334040

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.56
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdt1) DNA binding (Cdt1)
Anatomy Link Frequency
bone marrow 1
Cdt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 15 95.68 Very High Very High Very High
cINOD 15 5.00 Very Low Very Low Very Low
COX2 9 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cOX1 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 123 98.40 Very High Very High Very High
Apoptosis 45 91.04 High High
Lifespan 27 5.00 Very Low Very Low Very Low
Hypercalcemia 9 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Fracture Healing 9 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 6 5.00 Very Low Very Low Very Low
Bone Cancer 6 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, when we inhibited the COX-2 pathway using NS-398, the effect of Ris on cell viability was significantly reduced, at least at the highest concentrations.
Negative_regulation (reduced) of Ris
1) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.08 Pain Relevance 0.04
As for turnover, we observed decreased Activation Frequency in Ris treated rats, confirming our previous findings [16].


Negative_regulation (decreased) of Ris
2) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.27 Pain Relevance 0
We evaluated, using bone marrow stromal cells and MLO-y4 osteocytes, the effect of Ris at concentrations of 0, 0.1 to 10 ?
Negative_regulation (effect) of Ris in bone marrow
3) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.21 Pain Relevance 0.05

General Comments

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