INT334041

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.69
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdt1) DNA binding (Cdt1)
Anatomy Link Frequency
extremity 1
Cdt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 5 85.08 High High
Inflammatory response 1 83.84 Quite High
COX-2 inhibitor 20 74.24 Quite High
cINOD 20 60.44 Quite High
Pain 11 53.20 Quite High
cva 12 40.44 Quite Low
COX2 12 12.40 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 164 98.44 Very High Very High Very High
Thrombosis 39 95.72 Very High Very High Very High
Hemorrhage 19 93.92 High High
Lifespan 36 92.84 High High
Adhesions 1 85.60 High High
INFLAMMATION 13 83.48 Quite High
Apoptosis 60 83.40 Quite High
Cancer 4 80.80 Quite High
Syndrome 14 78.84 Quite High
Pressure And Volume Under Development 9 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concomitant increased expression of COX-2 and b-ALP genes after treatment with Ris suggests a direct effect on osteogenic differentiation of mesenchymal precursors.
Gene_expression (expression) of Ris
1) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.49 Pain Relevance 0.03
To confirm this hypothesis, we evaluated the effect of Ris at different concentrations on COX-2 as well as on b-ALP gene expression in vitro.
Gene_expression (expression) of Ris
2) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.72 Pain Relevance 0.12
The cultures were treated with Ris at concentrations ranging from 0.1 to 10 ?
Gene_expression (treated) of Ris
3) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0 Pain Relevance 0
Furthermore, increased COX-2 gene expression observed with Ris was maintained even in the presence of GC, suggesting that Ris counteracts negative effects of GC on osteoblastic lineage.


Gene_expression (expression) of Ris associated with osteoporosis
4) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.29 Pain Relevance 0.04
In conclusion, our study results showed that CDT with a continuous infusion of low-dose urokinase was effective in removing the clot burden and restoring the venous flow for the patients with non-acute lower extremity DVT, and our method reduced the incidence of bleeding complications and resulted in desirable mid-term outcomes.
Gene_expression (effective) of CDT in extremity associated with hemorrhage and thrombosis
5) Confidence 0.01 Published 2011 Journal Korean Journal of Radiology Section Body Doc Link PMC3017889 Disease Relevance 1.20 Pain Relevance 0.14

General Comments

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