INT334042

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdt1) DNA binding (Cdt1)
Cdt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 5 53.28 Quite High
COX2 3 43.04 Quite Low
COX-2 inhibitor 5 17.24 Low Low
analgesia 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cOX1 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 9 95.48 Very High Very High Very High
Osteoporosis 41 72.04 Quite High
Bone Cancer 2 69.04 Quite High
INFLAMMATION 3 51.84 Quite High
Apoptosis 15 5.00 Very Low Very Low Very Low
Hypercalcemia 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Fracture Healing 3 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 2 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest COX-2 as an important target of Ris and support the hypothesis that aminobisphosphonates may have an anabolic effect on bone by increasing both the lifespan and the number of active osteogenic cells.


Regulation (target) of Ris associated with lifespan
1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.42 Pain Relevance 0.05

General Comments

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