INT334153

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.00
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) transport (AQP4) extracellular region (CSF2)
plasma membrane (AQP4) transmembrane transport (AQP4) cytoplasm (AQP4)
Anatomy Link Frequency
blood 1
AQP4 (Homo sapiens)
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 24 98.92 Very High Very High Very High
intrathecal 54 92.00 High High
Neuritis 42 87.16 High High
Inflammation 18 77.32 Quite High
cytokine 3 66.64 Quite High
Central nervous system 12 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 15 99.20 Very High Very High Very High
Demyelinating Disease 48 98.92 Very High Very High Very High
Neuromyelitis Optica 72 98.08 Very High Very High Very High
Disease 42 93.36 High High
Recurrence 105 91.28 High High
Lumbar Puncture Related Headaches 6 88.16 High High
Optic Neuritis 42 87.16 High High
INFLAMMATION 18 77.32 Quite High
Acute Disease 12 46.28 Quite Low
Transverse Myelitis 9 33.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From 23 paired CSF and serum samples sufficient material was available for assessment of the AQP4-specific antibody index (AI), AIAQP4.
AQP4 Binding (assessment) of CSF
1) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 1.21 Pain Relevance 0.34
CSF AQP4-Ab might thus reflect passive diffusion of serum AQP4-Ab into the CSF.
AQP4 Binding (into) of CSF
2) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.78 Pain Relevance 0.27
AQP4-IgG CSF positivity was associated with higher AQP4-IgG serum titres and with dysfunction of the blood-CSF barrier.
AQP4-IgG Binding (associated) of CSF in blood
3) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 1.01 Pain Relevance 0.14

General Comments

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