INT334168

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
dentate gyrus 2
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 22 71.16 Quite High
gABA 7 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 10 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 2 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice heterozygous for the alpha-isoform of calcium/calmodulin-dependent protein kinase II, in which dentate gyrus granule cells fail to mature normally, TDO immunoreactivity was substantially downregulated in the dentate gyrus granule cells.
Negative_regulation (downregulated) of Regulation (immunoreactivity) of TDO in dentate gyrus
1) Confidence 0.38 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.04

General Comments

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