INT334180

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2) nucleus (Tbpl1) DNA binding (Tbpl1)
cytoplasm (Tbpl1)
Tdo2 (Mus musculus)
Tbpl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 3 96.68 Very High Very High Very High
Hippocampus 22 84.72 Quite High
sSRI 1 73.32 Quite High
fluoxetine 5 71.12 Quite High
antidepressant 2 70.12 Quite High
Nerve growth factor 1 19.12 Low Low
gABA 7 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 10 83.96 Quite High
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 2 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this pathway, TDO begins to catabolize Trp to produce kynurenine, the downstream substrate of the pathway, which produces several neurotoxic and neuroprotective intermediates [13].
TDO Negative_regulation (catabolize) of Trp
1) Confidence 0.10 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.16 Pain Relevance 0.45

General Comments

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