INT33419

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.15
Pain Relevance 7.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
NG108-15 6
embryonic kidney 4
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 36 100.00 Very High Very High Very High
Delta opioid receptors 12 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Kinase C 5 100.00 Very High Very High Very High
Immobilon 8 99.84 Very High Very High Very High
narcan 5 99.84 Very High Very High Very High
isoflurane 11 99.80 Very High Very High Very High
Morphine 16 98.64 Very High Very High Very High
Potency 13 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 8 99.68 Very High Very High Very High
Neuroblastoma 2 99.16 Very High Very High Very High
Glioma 2 98.52 Very High Very High Very High
Pheochromocytoma 10 98.04 Very High Very High Very High
INFLAMMATION 14 96.48 Very High Very High Very High
Hypoxia 10 96.36 Very High Very High Very High
Syndrome 6 95.96 Very High Very High Very High
Targeted Disruption 1 87.88 High High
Fever 2 77.76 Quite High
Reprotox - General 2 1 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of delta associated with kinase c, inflammation, syndrome and pheochromocytoma
1) Confidence 0.67 Published 2009 Journal Horm. Metab. Res. Section Title Doc Link 19048456 Disease Relevance 1.24 Pain Relevance 0.36
Increased expression of opioid delta receptors by deoxy conformation heme proteins in NG108-15 cells.
Positive_regulation (Increased) of Gene_expression (expression) of delta in NG108-15 associated with opioid
2) Confidence 0.67 Published 1995 Journal Brain Res. Section Title Doc Link 7614006 Disease Relevance 0.29 Pain Relevance 0.36
According to a cDNA microarray analysis, mRNA of protein kinase C-delta (PKC-delta), prostaglandin D synthase, and arachidonate release-relating enzymes were significantly overexpressed in the tumor tissue in comparison to the adjacent nontumor tissue.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of delta associated with kinase c and cancer
3) Confidence 0.49 Published 2009 Journal Horm. Metab. Res. Section Abstract Doc Link 19048456 Disease Relevance 1.42 Pain Relevance 0.42
In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons).
Positive_regulation (activated) of Gene_expression (expressed) of delta in embryonic kidney associated with gaba and isoflurane
4) Confidence 0.49 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.45 Pain Relevance 1.01
We report here the impact of mitogen-activated protein (MAP) kinase isoforms extracellular signal-regulated kinase (ERK)1/2 on the internalization of delta-opioid receptors (DORs) expressed in human embryonic kidney (HEK)293 cells.
Positive_regulation (impact) of Gene_expression (expressed) of delta in embryonic kidney associated with delta opioid receptors
5) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.68
The binding to opioid receptors was tested on crude membrane preparations from CHO cells stably transfected with the mu- and delta-opioid receptors.
Positive_regulation (transfected) of Gene_expression (transfected) of delta associated with delta opioid receptors and opioid receptor
6) Confidence 0.49 Published 2003 Journal J. Pept. Sci. Section Abstract Doc Link 14620129 Disease Relevance 0 Pain Relevance 0.45
We also investigated whether Trp318 and His319 provide the molecular basis for mu/delta selectivity and mu/kappa selectivity of morphinan alkaloids by mutating these residues to their corresponding residues in kappa- and delta-opioid receptors.
Positive_regulation (mutating) of Gene_expression (residues) of delta associated with delta opioid receptors
7) Confidence 0.49 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11705461 Disease Relevance 0.08 Pain Relevance 1.45
We find that co-expression of mu and delta receptors in heterologous cells followed by selective immunoprecipitation results in the isolation of mu-delta heterodimers.
Positive_regulation (results) of Gene_expression (co-expression) of delta
8) Confidence 0.49 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069979 Disease Relevance 0.08 Pain Relevance 0.86
Activation of cloned delta-opioid receptors stably expressed in GH(3) cells inhibits both spontaneous Ca(2+) signaling and basal prolactin release.
Positive_regulation (Activation) of Gene_expression (expressed) of delta associated with delta opioid receptors
9) Confidence 0.49 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10805669 Disease Relevance 0 Pain Relevance 0.33
In the present study, we tested the hypothesis that treatment of NG108-15 cells with metallic cations, which are known to induce a deoxygenated conformation of heme proteins, would increase delta opioid receptor (DOR) expression.
Positive_regulation (increase) of Gene_expression (expression) of delta in NG108-15 associated with opioid receptor
10) Confidence 0.45 Published 1995 Journal Brain Res. Section Abstract Doc Link 7614006 Disease Relevance 0.22 Pain Relevance 0.32
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Positive_regulation (increases) of Gene_expression (expression) of delta in NG108-15 associated with neuroblastoma, delta opioid receptors, glioma and immobilon
11) Confidence 0.45 Published 1986 Journal J. Biol. Chem. Section Title Doc Link 3005282 Disease Relevance 0.39 Pain Relevance 0.83

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