INT334212

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 8.84
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
brain 1
DLEU1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 99.78 Very High Very High Very High
Inflammation 18 99.60 Very High Very High Very High
substance P 5 97.72 Very High Very High Very High
Enkephalin 5 97.40 Very High Very High Very High
Neuropeptide 10 93.32 High High
Inflammatory marker 5 84.84 Quite High
imagery 10 78.16 Quite High
cocaine 5 45.52 Quite Low
Substantia nigra 10 32.56 Quite Low
Dopamine 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 780 100.00 Very High Very High Very High
Disease 694 100.00 Very High Very High Very High
Dementia 344 100.00 Very High Very High Very High
Disease Progression 20 100.00 Very High Very High Very High
Pain 5 99.78 Very High Very High Very High
INFLAMMATION 23 99.60 Very High Very High Very High
Syndrome 35 97.40 Very High Very High Very High
Alzheimer's Dementia 92 94.52 High High
Frontotemporal Lobar Degeneration 8 86.08 High High
Amyloid Plaque 25 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-synuclein reduction in early DLB, a correlation between CSF ?
Negative_regulation (reduction) of DLB associated with parkinson's disease
1) Confidence 0.28 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.24 Pain Relevance 0
Similarly, CSF measures of the precursor peptides for enkephalins and substance P (midregional proenkephalin A and N-terminal protachykinin A, resp.), involved in inflammation and pain, although decreased in dementia disorders, including DLB, appear not to have the power to differentiate various dementia syndromes from acute neuroinflammatory disorders [113], suggesting that the CSF measures of these two neuropeptide precursor fragments could reflect the extent of neuroinflammation and reduction in neuronal activity, common among these diseases.


Negative_regulation (decreased) of DLB in neuronal associated with parkinson's disease, pain, dementia, inflammation, syndrome, neuropeptide, enkephalin, disease and substance p
2) Confidence 0.20 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.99 Pain Relevance 0.46
42 loss in DLB subjects being accompanied by lower CSF levels of cystatin C [107], a peptide that inhibits fibril formation and oligomerization of the amyloid peptide [108].
Negative_regulation (loss) of DLB associated with parkinson's disease and alzheimer's dementia
3) Confidence 0.20 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.51 Pain Relevance 0.04
However, the CSF t-tau findings are not conclusive, and a contrary report of a decrease in t-tau in DLB was also described in a similar study conducted on autopsy-confirmed sample [61].
Negative_regulation (decrease) of DLB associated with parkinson's disease
4) Confidence 0.20 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.08 Pain Relevance 0
brain deposition between AD and DLB, in terms of the deposition occurring later in the course of DLB [109] or the faster rate of disease progression in DLB [32].In the Bibl et al. [64] study, a novel A?
Negative_regulation (progression) of DLB in brain associated with parkinson's disease, disease and disease progression
5) Confidence 0.20 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.90 Pain Relevance 0.03
In an associated study focussed on the biomarker supported differential diagnosis of AD, PD, PDD, and DLB, CSF A?
Negative_regulation (diagnosis) of DLB associated with parkinson's disease, dementia and disease
6) Confidence 0.09 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.13 Pain Relevance 0

General Comments

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