INT334219

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.21
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 80 90.04 High High
Inflammation 103 68.64 Quite High
Paracetamol 2 19.64 Low Low
agonist 5 11.88 Low Low
rheumatoid arthritis 25 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 60 96.80 Very High Very High Very High
Necrosis 11 96.32 Very High Very High Very High
Systemic Lupus Erythematosus 305 70.80 Quite High
INFLAMMATION 103 68.64 Quite High
Liver Disease 4 46.48 Quite Low
Autoimmune Disease 115 38.24 Quite Low
Hepatocellular Cancer 47 27.84 Quite Low
Hepatitis B Virus Infection 8 25.44 Quite Low
Hepatitis C Virus Infection 8 25.04 Quite Low
Alcoholic Liver Diseases 2 24.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like IRAK-M, IRAK1c cannot be phosphorylated by IRAK4 and thereby inhibits the dissociation of the complex, preventing activation of NF?
Phosphorylation (phosphorylated) of IRAK1c
1) Confidence 0.73 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.17 Pain Relevance 0.11
This adapter protein provides a scaffold for further interaction with IL-1R-associated kinase (IRAK) 1 and 4 to propagate the signal to downstream effectors via phosphorylation.
Phosphorylation (phosphorylation) of IRAK
2) Confidence 0.72 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.38 Pain Relevance 0.06
This short form of MyD88 fails to recruit IRAK4, impairing the ability to phosphorylate IRAK1, therefore preventing the activation of NF?
Phosphorylation (phosphorylate) of IRAK1
3) Confidence 0.72 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.12 Pain Relevance 0.19
Like IRAK-M, IRAK1c cannot be phosphorylated by IRAK4 and thereby inhibits the dissociation of the complex, preventing activation of NF?
Phosphorylation (phosphorylated) of IRAK
4) Confidence 0.72 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.17 Pain Relevance 0.11
IRAK4, in turn, activates IRAK1 via phosphorylation [28].
Phosphorylation (phosphorylation) of IRAK1
5) Confidence 0.56 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.37 Pain Relevance 0.08
IRAK4 in turn phosphorylates IRAK1, and IRAK2 promotes their association with TRAF6, which serves as a platform to recruit TAK1 kinase.
Phosphorylation (phosphorylates) of IRAK1
6) Confidence 0.46 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0

General Comments

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