INT334225

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak4) kinase activity (Irak4) cytoplasm (Irak4)
Irak4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 89.04 High High
Inflammation 39 33.36 Quite Low
Paracetamol 2 20.20 Low Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 44 86.40 High High
Necrosis 3 85.92 High High
Liver Disease 4 46.00 Quite Low
Autoimmune Disease 23 38.96 Quite Low
INFLAMMATION 39 33.36 Quite Low
Hepatocellular Cancer 47 28.40 Quite Low
Hepatitis B Virus Infection 8 24.96 Low Low
Hepatitis C Virus Infection 8 24.56 Low Low
Alcoholic Liver Diseases 2 24.16 Low Low
Nash(non-alcoholic Steatohepatitis) 9 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like IRAK-M, IRAK1c cannot be phosphorylated by IRAK4 and thereby inhibits the dissociation of the complex, preventing activation of NF?
Phosphorylation (phosphorylated) of IRAK4
1) Confidence 0.55 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.17 Pain Relevance 0.11
IRAK4 in turn phosphorylates IRAK1, and IRAK2 promotes their association with TRAF6, which serves as a platform to recruit TAK1 kinase.
Phosphorylation (phosphorylates) of IRAK4
2) Confidence 0.49 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0

General Comments

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