INT334230

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Anatomy Link Frequency
macrophages 1
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 19 89.72 High High
tolerance 42 88.40 High High
Inflammation 24 65.52 Quite High
agonist 4 37.24 Quite Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5 88.08 High High
Necrosis 3 87.60 High High
INFLAMMATION 25 65.52 Quite High
Infection 5 44.68 Quite Low
Disease 18 43.04 Quite Low
Sepsis 10 41.12 Quite Low
Autoimmune Disease 23 40.64 Quite Low
Systemic Lupus Erythematosus 61 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like IRAK-M, IRAK1c cannot be phosphorylated by IRAK4 and thereby inhibits the dissociation of the complex, preventing activation of NF?
Negative_regulation (inhibits) of IRAK1c
1) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.18 Pain Relevance 0.11
Contrary to the upregulation of IRAK-M, the critical signaling kinase, IRAK-1, is downregulated at the levels of protein and RNA in endotoxin-tolerant macrophages (17, 18).
Negative_regulation (downregulated) of IRAK-1 in macrophages
2) Confidence 0.20 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.12 Pain Relevance 0.40

General Comments

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