INT334237

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.16
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 69.92 Quite High
cytokine 42 59.48 Quite High
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 183 86.84 High High
INFLAMMATION 48 69.92 Quite High
Autoimmune Disease 69 69.60 Quite High
Renal Disease 9 52.32 Quite High
Sprains And Strains 6 25.00 Low Low
Disease 48 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this mimic showed an inhibition of MyD88 and IL-1RI interaction by ablating phosphorylation of MAP kinases [86].
Negative_regulation (inhibition) of MyD88 Binding (interaction) of
1) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.40 Pain Relevance 0.06
This inhibitor showed similar inhibition of MyD88 signaling indicated by impaired NF?
Negative_regulation (inhibition) of MyD88 Binding (indicated) of
2) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.38 Pain Relevance 0.03
They also went on to show that not only do these peptides inhibit dimerization of MyD88, but also inhibit the recruitment of IRAK1 and IRAK4 [88].
Negative_regulation (inhibit) of MyD88 Neg (inhibit) Binding (dimerization) of
3) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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