INT334241

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.09
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 70 99.40 Very High Very High Very High
Inflammation 80 73.36 Quite High
agonist 5 13.56 Low Low
rheumatoid arthritis 25 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 305 81.84 Quite High
Cancer 20 81.52 Quite High
Necrosis 10 81.04 Quite High
INFLAMMATION 80 73.36 Quite High
Autoimmune Disease 115 52.68 Quite High
Renal Disease 15 35.40 Quite Low
Disease 80 19.08 Low Low
Sprains And Strains 10 8.08 Low Low
Apoptosis 25 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This adapter protein provides a scaffold for further interaction with IL-1R-associated kinase (IRAK) 1 and 4 to propagate the signal to downstream effectors via phosphorylation.
IRAK Binding (interaction) of
1) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.37 Pain Relevance 0.07
Kobayashi et al. showed that IRAK-M, which lacks the kinase activity of its counterparts IRAK1 and IRAK4, suppresses the production of proinflammatory cytokines and proposed a model whereby IRAK-M prevents the dissociation of the IRAK1/IRAK4/MyD88 complex to inhibit downstream NF?
IRAK1 Binding (counterparts) of associated with cytokine
2) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.11 Pain Relevance 0.09
They also went on to show that not only do these peptides inhibit dimerization of MyD88, but also inhibit the recruitment of IRAK1 and IRAK4 [88].
IRAK1 Neg (inhibit) Binding (recruitment) of
3) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.33 Pain Relevance 0.04
Kobayashi et al. showed that IRAK-M, which lacks the kinase activity of its counterparts IRAK1 and IRAK4, suppresses the production of proinflammatory cytokines and proposed a model whereby IRAK-M prevents the dissociation of the IRAK1/IRAK4/MyD88 complex to inhibit downstream NF?
IRAK Binding (dissociation) of associated with cytokine
4) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.13 Pain Relevance 0.09
Kobayashi et al. showed that IRAK-M, which lacks the kinase activity of its counterparts IRAK1 and IRAK4, suppresses the production of proinflammatory cytokines and proposed a model whereby IRAK-M prevents the dissociation of the IRAK1/IRAK4/MyD88 complex to inhibit downstream NF?
IRAK1 Binding (complex) of associated with cytokine
5) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.14 Pain Relevance 0.09

General Comments

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