INT334257

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1, Irak4) kinase activity (Irak1, Irak4) cytoplasm (Irak1, Irak4)
nucleus (Irak1)
Irak1 (Mus musculus)
Irak4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 28 93.04 High High
Inflammation 32 74.16 Quite High
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 122 82.64 Quite High
Cancer 8 81.92 Quite High
Necrosis 4 81.44 Quite High
INFLAMMATION 32 74.16 Quite High
Autoimmune Disease 46 52.68 Quite High
Renal Disease 6 35.40 Quite Low
Sprains And Strains 4 8.08 Low Low
Disease 32 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, the splice variant IRAK1c acts in a similar manner by interacting with MyD88 and IRAK4.
IRAK1c Binding (interacting) of IRAK4
1) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.16 Pain Relevance 0.09
They also went on to show that not only do these peptides inhibit dimerization of MyD88, but also inhibit the recruitment of IRAK1 and IRAK4 [88].
IRAK1 Neg (inhibit) Binding (recruitment) of IRAK4
2) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.33 Pain Relevance 0.04

General Comments

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