INT334258

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Myd88, Irak4) cytoplasm (Myd88, Irak4) cytosol (Myd88)
plasma membrane (Myd88) intracellular (Myd88) kinase activity (Irak4)
Myd88 (Mus musculus)
Irak4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 96.56 Very High Very High Very High
cytokine 34 42.00 Quite Low
Paracetamol 4 23.32 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 96.56 Very High Very High Very High
Systemic Lupus Erythematosus 61 92.04 High High
Liver Disease 8 41.92 Quite Low
Autoimmune Disease 23 34.64 Quite Low
Disease 18 33.12 Quite Low
Hepatocellular Cancer 94 31.52 Quite Low
Hepatitis 14 22.32 Low Low
Hepatitis B Virus Infection 16 20.88 Low Low
Hepatitis C Virus Infection 16 20.48 Low Low
Alcoholic Liver Diseases 4 20.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Briefly, IRAK4 is a kinase that interacts with MyD88 and TRAF6 and is associated with the activation of the downstream transcription factors in TLR signaling.
MyD88 Binding (interacts) of IRAK4
1) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.24 Pain Relevance 0.05
In the MyD88-dependent pathway, MyD88 is associated with IRAK4, IRAK1, and/or IRAK2.
MyD88-dependent Binding (associated) of IRAK4
2) Confidence 0.25 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0
In the MyD88-dependent pathway, MyD88 is associated with IRAK4, IRAK1, and/or IRAK2.
MyD88 Binding (associated) of IRAK4
3) Confidence 0.25 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0

General Comments

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