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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf4, Irf5) DNA binding (Irf4, Irf5) cytoplasm (Irf4)
Irf4 (Mus musculus)
Irf5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 99.76 Very High Very High Very High
rheumatoid arthritis 5 50.72 Quite High
corticosteroid 1 13.92 Low Low
cINOD 1 11.20 Low Low
Inflammation 16 6.32 Low Low
antagonist 3 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 23 90.96 High High
Necrosis 2 82.32 Quite High
Cancer 4 81.96 Quite High
Diabetes Mellitus 3 51.52 Quite High
Rheumatoid Arthritis 5 50.72 Quite High
Systemic Lupus Erythematosus 61 48.64 Quite Low
Disease 16 28.56 Quite Low
INFLAMMATION 16 10.80 Low Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Renal Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By IRF4 competing with IRF5 for binding, it inhibits the activation of IRF5 thus impairing IRF5-mediated cytokine production.


IRF4 Binding (competing) of IRF5 associated with cytokine
1) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.42 Pain Relevance 0.18

General Comments

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