INT334262

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Myd88, Tlr7) cytoplasm (Myd88, Tlr7) signal transduction (Myd88, Tlr7)
plasma membrane (Myd88, Tlr7) endosome (Tlr7) endoplasmic reticulum (Tlr7)
Myd88 (Mus musculus)
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 89.96 High High
cytokine 14 39.92 Quite Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 61 94.20 High High
INFLAMMATION 16 89.96 High High
Autoimmune Disease 23 50.04 Quite High
Renal Disease 3 32.76 Quite Low
Sprains And Strains 2 5.44 Low Low
Disease 16 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of the fact that MyD88 is a central mediator in TLR 7 and 9 signaling, these inhibitors of MyD88 dimerization and recruitment of essential kinases could prove to be an effective treatment option in lupus by abolishing the aberrant TLR signaling that induces the elevated type I IFN levels and persistent inflammation.
MyD88 Positive_regulation (mediator) of TLR 7 associated with inflammation and systemic lupus erythematosus
1) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.30 Pain Relevance 0.04

General Comments

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