INT334310

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 3.88
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Mtx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 650 100.00 Very High Very High Very High
cytokine 247 88.12 High High
Inflammation 546 87.72 High High
anesthesia 13 67.08 Quite High
Inflammatory mediators 13 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
Inflammatory response 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 78 95.64 Very High Very High Very High
Enteritis 221 92.96 High High
INFLAMMATION 559 87.72 High High
Colitis 26 76.40 Quite High
Urological Neuroanatomy 104 58.00 Quite High
Enteropathy 26 56.96 Quite High
Inflammatory Bowel Disease 65 55.40 Quite High
Pathologic Processes 13 38.68 Quite Low
Stress 13 34.68 Quite Low
Infection 39 30.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.52
N-acetylcysteine (NAC) and MTX were purchased in Zhejiang Wanma Pharmaceutical Co., Ltd. and Shanghai Sunve Pharmaceutical Co., Ltd. respectively.

5 The disease activity index (DAI), colonic mucosal damage index (CMDI) and histological score (HS) of the rats were evaluated

Gene_expression (purchased) of MTX associated with disease and methotrexate
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.38
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.52
7 days after MTX injection, the rats were anesthetized and a 3 mL sample of venous blood was collected.
Gene_expression (injection) of MTX in blood associated with methotrexate
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.26 Pain Relevance 0.10
0.000), while it in MTX+curcumin group and MTX+NAC group were both lower than it in control group (p<0.01) but higher than it MTX group (p?
Gene_expression (group) of MTX+NAC associated with methotrexate
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.16 Pain Relevance 0.36
0.000), while it in MTX+curcumin group and MTX+NAC group were both lower than it in control group (p<0.01) but higher than it MTX group (p?
Gene_expression (group) of MTX associated with methotrexate
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.15 Pain Relevance 0.35
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.56
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.34 Pain Relevance 0.52
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.52
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.34 Pain Relevance 0.55
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.52
0.000), while it in MTX+curcumin group and MTX+NAC group were both lower than it in control group (p<0.01) but higher than it MTX group (p?
Gene_expression (group) of MTX associated with methotrexate
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.16 Pain Relevance 0.36
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Gene_expression (group) of MTX associated with methotrexate
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.35 Pain Relevance 0.52

General Comments

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