INT334320

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0

plasma membrane (EGFR, RASGRP1) endoplasmic reticulum (EGFR, RASGRP1) Golgi apparatus (EGFR, RASGRP1) cytoplasm (EGFR, RASGRP1) signal transduction (EGFR, RASGRP1) cell differentiation (RASGRP1)

EGFR (Homo sapiens) RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 2 5.00 local anesthetic 1 5.00

Disease Link Frequency Relevance Heat Cancer 105 98.04 Hyperplasia 1 84.44 Apoptosis 2 82.20 Adenocarcinoma 8 50.00 Congenital Anomalies 1 39.12 Lung Cancer 8 36.72 Thyroid Neoplasm 1 29.92 Metastasis 15 5.00 Recurrence 11 5.00 Disease 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The high expression of RET (which, like EGFR, activates the RAS/ERK pathway) provides a plausible explanation of the failure of erlotinib to control proliferation of this tumor.

EGFR Positive_regulation (activates) of RAS associated with cancer

1) Confidence 0.05 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.76 Pain Relevance 0

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