INT334322

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1, TP53) DNA binding (RB1, TP53) nucleus (RB1, TP53)
transcription factor binding (RB1, TP53) cell differentiation (TP53) mitochondrion (TP53)
RB1 (Homo sapiens)
TP53 (Homo sapiens)
TP53 - D259Y (1)
Pain Link Frequency Relevance Heat
positron emission tomography 4 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 210 99.62 Very High Very High Very High
Metastasis 30 63.68 Quite High
Adenocarcinoma 16 50.00 Quite Low
Lung Cancer 16 28.64 Quite Low
Recurrence 22 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Skin Cancer 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Renal Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatic mutations were observed in two well characterized tumor suppressor genes, TP53 (D259Y) and a truncating mutation in RB1 (L234*) removing 75% of its coding sequence [24], with TP53 also within a region of heterozygous loss (LOH).


RB1 Binding (mutation) of TP53 (D259Y) associated with cancer
1) Confidence 0.34 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.98 Pain Relevance 0
Somatic mutations were observed in two well characterized tumor suppressor genes, TP53 (D259Y) and a truncating mutation in RB1 (L234*) removing 75% of its coding sequence [24], with TP53 also within a region of heterozygous loss (LOH).


RB1 Binding (mutation) of TP53 associated with cancer
2) Confidence 0.34 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 1.03 Pain Relevance 0

General Comments

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