INT334324

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.81 Pain Relevance 0

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 2 5.00 local anesthetic 1 5.00

Disease Link Frequency Relevance Heat Cancer 105 98.96 Hyperplasia 1 89.60 Apoptosis 2 87.36 Adenocarcinoma 8 50.00 Lung Cancer 8 36.04 Thyroid Neoplasm 1 35.08 Congenital Anomalies 1 30.88 Metastasis 15 5.00 Recurrence 11 5.00 Disease 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These changes mitigate the effect of PTEN loss on the PI3K/AKT pathway and suggest that the loss of PTEN serves primarily to further activate the RET pathway to drive tumor growth.

Positive_regulation (activate) of Negative_regulation (loss) of PTEN associated with cancer

1) Confidence 0.41 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.81 Pain Relevance 0

General Comments

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