INT334327

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMAD4) intracellular (SMAD4) protein binding transcription factor activity (SMAD4)
DNA binding (SMAD4) cytoplasm (SMAD4) cytosol (SMAD4)
SMAD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 150 98.76 Very High Very High Very High
Pancreatic Cancer 25 97.64 Very High Very High Very High
Death 14 94.16 High High
Metastasis 19 92.80 High High
Adenocarcinoma 18 68.16 Quite High
Apoptosis 21 61.44 Quite High
Disease 12 50.00 Quite Low
Recurrence 11 5.00 Very Low Very Low Very Low
Lung Cancer 8 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, down-regulation of Smad4 along with loss of 18q also appear to be properties of the tumor.
Regulation (regulation) of Smad4 associated with cancer
1) Confidence 0.35 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.93 Pain Relevance 0
Moreover, a number of other genetic alterations for several specific genes including p53, p16INK4a, and Smad4, have been documented [58].
Regulation (alterations) of Smad4
2) Confidence 0.33 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.80 Pain Relevance 0

General Comments

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