INT334351

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) extracellular region (Bdnf)
plasma membrane (Ephb1) cytoplasmic membrane-bounded vesicle (Bdnf) cytoplasm (Ephb1)
Bdnf (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 77 99.68 Very High Very High Very High
nMDA receptor antagonist 1 97.04 Very High Very High Very High
Neuropathic pain 16 94.48 High High
Hyperalgesia 10 93.64 High High
Inflammation 9 93.12 High High
nMDA receptor 1 92.24 High High
Dorsal horn 9 83.12 Quite High
Peripheral nerve injury 1 78.80 Quite High
5HT 15 76.96 Quite High
projection neuron 7 64.44 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 19 94.48 High High
Hyperalgesia 11 93.64 High High
INFLAMMATION 9 93.12 High High
Nociception 4 90.16 High High
Hypersensitivity 7 89.60 High High
Urological Neuroanatomy 4 84.92 Quite High
Nervous System Injury 53 78.80 Quite High
Injury 4 50.00 Quite Low
Pain 15 5.00 Very Low Very Low Very Low
Amputation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF has been shown in other systems to activate ERK [44] and a role of released BDNF in the activation of ERK in the RVM seems likely.


BDNF Regulation (role) of Positive_regulation (activation) of ERK associated with rostral ventromedial medulla
1) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.27 Pain Relevance 1.20

General Comments

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