INT33442

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Context Info
Confidence 0.04
First Reported 1986
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (ADRB1) plasma membrane (ADRB1) nucleus (ADRB1)
cytoplasm (ADRB1) signal transducer activity (ADRB1)
Anatomy Link Frequency
blood 1
knee joints 1
ADRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 99.96 Very High Very High Very High
Inflammation 6 94.76 High High
anesthesia 2 94.76 High High
Clonidine 9 91.00 High High
Arthritis 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 97.40 Very High Very High Very High
INFLAMMATION 1 94.76 High High
Hypertension 2 75.00 Quite High
Heart Rate Under Development 1 61.64 Quite High
Arthritis 3 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The selective alpha-2 adrenoceptor agonist, BHT-920, injected i.c.v. (5-50 micrograms) also produced a dose-dependent pressor response which was abolished by either anesthesia or central pretreatment with yohimbine, but not with prazosin, whereas the selective alpha-1 adrenoceptor agonist, methoxamine (10-100 micrograms i.c.v.), caused a slight increase in mean blood pressure only at higher doses.
Regulation (selective) of adrenoceptor in blood associated with anesthesia and agonist
1) Confidence 0.04 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3005557 Disease Relevance 0.19 Pain Relevance 0.70
To determine whether this phenomenon is due to an alteration in smooth muscle adrenoceptor function, the present study compared the alpha-adrenoceptor profile of blood vessels supplying the anteromedial capsule of normal and chronically inflamed rat knee joints.
Spec (whether) Regulation (alteration) of adrenoceptor in knee joints
2) Confidence 0.03 Published 2001 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 11506997 Disease Relevance 0.19 Pain Relevance 0.28

General Comments

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